consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy