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Interaction Check

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Selected Drugs Clear All

  • remove Acanya
    clindamycin/ benzoyl peroxide topical
  • remove Acuvail
    ketorolac ophthalmic
  • remove ampicillin
    generic
  • remove Envarsus XR
    tacrolimus
  • remove ketoprofen
    generic
  • remove Modicon
    norethindrone/ ethinyl estradiol
  • remove Morphabond ER
    morphine sulfate
  • remove RectiCare Advanced Cream
    lidocaine/ phenylephrine/ mineral oil/ petrolatum topical
  • remove Xopenex HFA
    levalbuterol inhaled
  • remove Xulane
    norelgestromin/ ethinyl estradiol transdermal

multicheck MultiCheck Results - 15 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Envarsus XR (tacrolimus) + ketoprofen (generic)

Avoid/Use Alternative


tacrolimus + ketoprofen

consider alternative or monitor tacrolimus levels, renal fxn, BP, potassium: combo may incr. tacrolimus levels, risk of nephrotoxicity, HTN, hyperkalemia, other adverse effects (additive effects)

Smiley face Smiley face Modicon (norethindrone/ ethinyl estradiol) + Xulane (norelgestromin/ ethinyl estradiol transdermal)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

norethindrone (contraceptive) + norelgestromin (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Acuvail (ketorolac ophthalmic) + ketoprofen (generic)

Monitor/Modify Tx


ketorolac ophthalmic + ketoprofen

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

Smiley face Smiley face Envarsus XR (tacrolimus) + Modicon (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


tacrolimus + ethinyl estradiol (contraceptive)

monitor tacrolimus levels, ECG, BP, renal fxn: combo may incr. tacrolimus levels, risk of QT prolongation, cardiac arrhythmias, HTN, nephrotoxicity, other adverse effects (hepatic metabolism inhibited, additive effects)

Smiley face Smiley face Envarsus XR (tacrolimus) + Morphabond ER (morphine sulfate)

Monitor/Modify Tx


tacrolimus + morphine

monitor respiratory rate, consider decr. dose of one or both drugs: combo may incr. morphine levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (P-gp-mediated transport possibly inhibited)

Smiley face Smiley face Envarsus XR (tacrolimus) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


tacrolimus + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Envarsus XR (tacrolimus) + Xulane (norelgestromin/ ethinyl estradiol transdermal)

Monitor/Modify Tx


tacrolimus + ethinyl estradiol (contraceptive)

monitor tacrolimus levels, ECG, BP, renal fxn: combo may incr. tacrolimus levels, risk of QT prolongation, cardiac arrhythmias, HTN, nephrotoxicity, other adverse effects (hepatic metabolism inhibited, additive effects)

Smiley face Smiley face ketoprofen (generic) + Modicon (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


ketoprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ketoprofen + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face ketoprofen (generic) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


ketoprofen + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face ketoprofen (generic) + Xulane (norelgestromin/ ethinyl estradiol transdermal)

Monitor/Modify Tx


ketoprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ketoprofen + norelgestromin (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face Modicon (norethindrone/ ethinyl estradiol) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Xopenex HFA (levalbuterol inhaled) + Xulane (norelgestromin/ ethinyl estradiol transdermal)

Monitor/Modify Tx


levalbuterol inhaled + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face morphine in Morphabond ER

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy

Smiley face Smiley face tacrolimus in Envarsus XR

monitor tacrolimus levels in combo with HCV Direct Acting Antiviral (DAA) tx; viral eradication may improve hepatic metabolic function, alter tacrolimus levels, efficacy

avoid combo with beverages or products containing ethanol and tacrolimus extended-release (ER) formulations; combo may incr. tacrolimus release rate, levels, risk of adverse effects, decr. duration of efficacy

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