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Interaction Check

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Selected Drugs Clear All

  • remove Carduus marianus
    milk thistle (Silybum marianum)
  • remove Dengvaxia
    dengue tetravalent vaccine, live (DEN4CYD)
  • remove Lazanda
    fentanyl nasal
  • remove oil of peppermint
    peppermint (Mentha x piperita)
  • remove Xanax
    alprazolam

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Lazanda (fentanyl nasal) + Xanax (alprazolam)

Avoid/Use Alternative


fentanyl + alprazolam

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. fentanyl levels, risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, additive effects)

Smiley face Smiley face oil of peppermint (peppermint (Mentha x piperita)) + Xanax (alprazolam)

Avoid/Use Alternative


peppermint + alprazolam

use alternative or monitor respiratory rate; consider decr. alprazolam dose: combo may incr. alprazolam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

Monitor/Modify Tx

Smiley face Smiley face Lazanda (fentanyl nasal) + oil of peppermint (peppermint (Mentha x piperita))

Monitor/Modify Tx


fentanyl + peppermint

monitor respiratory rate, consider decr. fentanyl dose: combo may incr. fentanyl levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

Additional Considerations

Smiley face Smiley face fentanyl in Lazanda

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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