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Interaction Check

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Selected Drugs Clear All

  • remove Ajovy (fremanezumab-vfrm)
    fremanezumab
  • remove Aviane
    levonorgestrel/ ethinyl estradiol
  • remove Lessina
    levonorgestrel/ ethinyl estradiol
  • remove mycophenolate mofetil
    generic
  • remove Ziac
    bisoprolol/ hydrochlorothiazide

multicheck MultiCheck Results - 12 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Aviane (levonorgestrel/ ethinyl estradiol) + Lessina (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

levonorgestrel (contraceptive) + levonorgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Aviane (levonorgestrel/ ethinyl estradiol) + mycophenolate mofetil (generic)

Avoid/Use Alternative


levonorgestrel (contraceptive) + mycophenolate mofetil

use additional non-hormonal or alternative contraception: combo may decr. levonorgestrel levels, contraceptive efficacy (mechanism unknown)

Smiley face Smiley face Lessina (levonorgestrel/ ethinyl estradiol) + mycophenolate mofetil (generic)

Avoid/Use Alternative


levonorgestrel (contraceptive) + mycophenolate mofetil

use additional non-hormonal or alternative contraception: combo may decr. levonorgestrel levels, contraceptive efficacy (mechanism unknown)

Monitor/Modify Tx

Smiley face Smiley face Ajovy (fremanezumab-vfrm) (fremanezumab) + Aviane (levonorgestrel/ ethinyl estradiol)

Monitor/Modify Tx


fremanezumab + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Ajovy (fremanezumab-vfrm) (fremanezumab) + Lessina (levonorgestrel/ ethinyl estradiol)

Monitor/Modify Tx


fremanezumab + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Ajovy (fremanezumab-vfrm) (fremanezumab) + Ziac (bisoprolol/ hydrochlorothiazide)

Monitor/Modify Tx


fremanezumab + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

fremanezumab + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face Aviane (levonorgestrel/ ethinyl estradiol) + Ziac (bisoprolol/ hydrochlorothiazide)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

ethinyl estradiol (contraceptive) + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face Lessina (levonorgestrel/ ethinyl estradiol) + Ziac (bisoprolol/ hydrochlorothiazide)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

ethinyl estradiol (contraceptive) + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Additional Considerations

Smiley face Smiley face mycophenolate mofetil

mycophenolate mofetil (prodrug) converted to mycophenolic acid

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