Interaction Check

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MultiCheck Results - 3 Interactions

Monitor/Modify Tx
diphenoxylate/atropine (generic) + morphine sulfate (generic)
Monitor/Modify Tx diphenoxylate + morphine monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects) Caution Advised atropine + morphine caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)
Caution Advised
morphine sulfate (generic) + polyethylene glycol 3350 (generic)
Caution Advised morphine + polyethylene glycol caution advised, especially if polyethylene glycol bowel prep use: combo may incr. risk of seizures (additive effects)
Additional Considerations
morphine in morphine sulfate
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy
polyethylene glycol in polyethylene glycol 3350
separate administration from other oral drugs by at least 1h; polyethylene glycol when used for bowel prep may decr. absorption of concomitant oral drugs