Selected Drugs Clear All

  • remove Kytril
    granisetron
  • remove Nucynta
    tapentadol

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative
Smiley face Smiley face Kytril (granisetron) + Nucynta (tapentadol)

Avoid/Use Alternative

granisetron + tapentadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Additional Considerations
Smiley face Smiley face tapentadol in Nucynta

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and tapentadol extended-release (ER) tablets; combo may incr. tapentadol release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy
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