Selected Drugs Clear All
MultiCheck Results
- 1
Interaction
Monitor/Modify Tx |
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Epclusa
(sofosbuvir/ velpatasvir) + Prograf
(tacrolimus) |
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Additional Considerations |
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tacrolimus
in Prograf
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monitor tacrolimus levels in combo with HCV Direct Acting Antiviral (DAA) tx; viral eradication may improve hepatic metabolic function, alter tacrolimus levels, efficacy avoid combo with beverages or products containing ethanol and tacrolimus extended-release (ER) formulations; combo may incr. tacrolimus release rate, levels, risk of adverse effects, decr. duration of efficacy |
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sofosbuvir
in Epclusa
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caution advised w/ narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose w/ drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia |
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velpatasvir
in Epclusa
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caution advised w/ narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose w/ drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia |
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