Selected Drugs Clear All
MultiCheck Results
- 1
Interaction
Monitor/Modify Tx |
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Norco
(hydrocodone/ acetaminophen) + Pentam
(pentamidine) |
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Monitor/Modify Txhydrocodone + pentamidine monitor ECG, electrolytes, BP, especially if hydrocodone ER doses >160 mg/day; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias, severe or life-threatening hypotension, including orthostasis, syncope (additive effects) |
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Additional Considerations |
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hydrocodone
in Norco
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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