flibanserin + codeine

avoid combo if antitussive use; otherwise, use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine; additive effects)

diclofenac + acetaminophen

use alternative or monitor LFTs; use lowest effective doses, shortest effective tx duration: combo may incr. risk of hepatotoxicity (possible additive effects)