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Interaction Check

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Selected Drugs Clear All

  • remove Anaprox DS
    naproxen sodium
  • remove aswagandha
    ashwagandha (Withania somnifera)
  • remove clorazepate
    generic
  • remove desipramine
    generic
  • remove Keflex
    cephalexin
  • remove norethindrone/ ethinyl estradiol
    generic

multicheck MultiCheck Results - 4 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Anaprox DS (naproxen sodium) + norethindrone/ethinyl estradiol (generic)

Monitor/Modify Tx


naproxen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective naproxen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

naproxen + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective naproxen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face clorazepate (generic) + desipramine (generic)

Monitor/Modify Tx


clorazepate + desipramine

monitor respiratory rate; caution advised if seizure disorder use: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desipramine may decr. seizure threshold)

Smiley face Smiley face desipramine (generic) + norethindrone/ethinyl estradiol (generic)

Monitor/Modify Tx


desipramine + ethinyl estradiol (contraceptive)

monitor ECG; consider monitoring desipramine levels: combo may incr. desipramine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

Additional Considerations

Smiley face Smiley face desipramine

add MAO inhibitor to Interaction Check if recent (14 days) use

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