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Interaction Check

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Selected Drugs Clear All

  • remove pioglitazone
    generic
  • remove valproate sodium
    generic
  • remove Vicks NyQuil Severe Cold & Flu + Congestion w/ VapoCOOL
    acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face valproate sodium (generic) + Vicks NyQuil Severe Cold & Flu + Congestion w/ VapoCOOL (acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine)

Avoid/Use Alternative


valproic acid + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx


valproic acid + acetaminophen

consider acetaminophen dose adjustment: combo may incr. acetaminophen levels, risk of adverse effects (UGT inhibited)

Monitor/Modify Tx

Smiley face Smiley face pioglitazone (generic) + Vicks NyQuil Severe Cold & Flu + Congestion w/ VapoCOOL (acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine)

Monitor/Modify Tx


pioglitazone + phenylephrine

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Vicks NyQuil Severe Cold & Flu + Congestion w/ VapoCOOL

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Vicks NyQuil Severe Cold & Flu + Congestion w/ VapoCOOL

add MAO inhibitor to Interaction Check if recent (14 days) use

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