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Interaction Check

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Selected Drugs Clear All

  • remove azithromycin
    generic
  • remove codeine/ guaifenesin
    generic
  • remove Larissia
    levonorgestrel/ ethinyl estradiol
  • remove trebol rojo
    red clover (Trifolium pratense)

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face codeine/guaifenesin (generic) + Larissia (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


codeine + ethinyl estradiol (contraceptive)

use alternative or monitor respiratory rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism inhibited, may alter production of active metabolite morphine)

Additional Considerations

Smiley face Smiley face codeine in codeine/guaifenesin

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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