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Interaction Check

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Selected Drugs Clear All

  • remove Combipatch
    estradiol/ norethindrone acetate transdermal
  • remove desvenlafaxine
    generic
  • remove Norditropin
    somatropin (recombinant)

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Combipatch (estradiol/ norethindrone acetate transdermal) + Norditropin (somatropin (recombinant))

Monitor/Modify Tx


estradiol (hormone replacement) + somatropin

consider incr. somatropin dose: combo may decr. somatropin efficacy (antagonistic effects, oral estrogens may reduce serum IGF-1 response)

Additional Considerations

Smiley face Smiley face desvenlafaxine

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face somatropin in Norditropin

caution advised with drugs metabolized by CYP450 liver enzymes; somatropin may increase CYP450 metabolic function, alter levels of concomitant drugs, incr. risk of adverse effects or decr. efficacy

lonapegsomatropin is a prodrug of somatropin; similar interactions anticipated

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