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Interaction Check

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Selected Drugs Clear All

  • remove Cresemba
    isavuconazonium sulfate
  • remove Daytrana
    methylphenidate transdermal
  • remove Mephyton
    phytonadione (vitamin K1)
  • remove Phillips' Milk of Magnesia
    magnesium hydroxide
  • remove Sandostatin
    octreotide
  • remove Tindamax
    tinidazole

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Daytrana (methylphenidate transdermal) + Phillips' Milk of Magnesia (magnesium hydroxide)

Avoid/Use Alternative


methylphenidate + magnesium hydroxide

consider alternative w/ some oral methylphenidate ER formulations: combo may alter methylphenidate release, incr. risk of adverse effects or decr. efficacy (altered dissolution of ER methylphenidate at higher gastric pH)

Monitor/Modify Tx

Smiley face Smiley face Phillips' Milk of Magnesia (magnesium hydroxide) + Sandostatin (octreotide)

Monitor/Modify Tx


magnesium hydroxide + octreotide

consider giving oral octreotide 2h before or after magnesium hydroxide: combo may decr. octreotide levels, efficacy (absorption decreased at higher gastric pH)

Additional Considerations

Smiley face Smiley face methylphenidate in Daytrana

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face isavuconazonium in Cresemba

isavuconazonium (prodrug) converted to isavuconazole

Smiley face Smiley face tinidazole in Tindamax

avoid combo with alcoholic beverages or products containing ethanol or propylene glycol during and x3 days after tinidazole tx; combo may incr. risk of disulfiram-like reaction

Smiley face Smiley face octreotide in Sandostatin

caution advised with narrow therapeutic index drugs extensively metabolized by CYP450 liver enzymes; octreotide inhibition of growth hormone production may decr. CYP450 metabolic function, incr. levels of concomitant drugs, risk of adverse effects

caution advised with oral drugs; octreotide alters nutrient absorption, may alter absorption of concomitant drugs, incr. risk of adverse effects or decr. efficacy

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