contraindicated with alcoholic beverages or products containing ethanol or propylene glycol during and x3 days after metronidazole vaginal 5-day tx or x24h after metronidazole vaginal single dose tx; combo may incr. risk of disulfiram-like reaction

caution advised w/ narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx w/ immune modulators may reverse this effect, resulting in altered levels of concomitant drugs