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Interaction Check

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Selected Drugs Clear All

  • remove imipramine
    generic
  • remove Quillivant XR
    methylphenidate

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face imipramine (generic) + Quillivant XR (methylphenidate)

Monitor/Modify Tx


imipramine + methylphenidate

monitor BP, HR, serotonin syndrome symptoms, especially during initiation/titration; consider monitoring imipramine levels: combo may incr. imipramine levels, risk of HTN, tachycardia, serotonin syndrome, other adverse effects (mechanism unknown, hepatic metabolism possibly inhibited, additive effects)

Additional Considerations

Smiley face Smiley face methylphenidate in Quillivant XR

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face imipramine

add MAO inhibitor to Interaction Check if recent (14 days) use

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