Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Monitor/Modify Tx |
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Tussionex PennKinetic
(chlorpheniramine/ hydrocodone) + Zestoretic
(lisinopril/ hydrochlorothiazide) |
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Monitor/Modify Txhydrocodone + hydrochlorothiazide monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope; may decr. hydrochlorothiazide efficacy (additive effects; antagonistic effects, opioids may induce antidiuretic hormone release) hydrocodone + lisinopril monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects) Caution Advisedchlorpheniramine + hydrochlorothiazide caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased) |
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Additional Considerations |
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hydrocodone
in Tussionex PennKinetic
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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