Interaction Check

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MultiCheck Results - 7 Interactions

Contraindicated
edoxaban (generic) + Mifeprex (mifepristone (gynecologic))
Contraindicated edoxaban + mifepristone contraindicated if pregnancy termination use; monitor bleeding s/sx if daily mifepristone use: combo may incr. edoxaban levels, risk of severe or prolonged vaginal bleeding or other bleeding, other adverse effects (P-gp-mediated transport inhibited, additive effects)
Avoid/Use Alternative
Incassia (norethindrone) + Mifeprex (mifepristone (gynecologic))
Avoid/Use Alternative norethindrone (contraceptive) + mifepristone use alternative non-hormonal contraception during and x1mo after daily mifepristone use: combo may decr. hormonal contraceptive efficacy (antagonistic effects)
Incassia (norethindrone) + Necon 1/35 (norethindrone/ ethinyl estradiol)
Avoid/Use Alternative norethindrone (contraceptive) + norethindrone (contraceptive) avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)
Mifeprex (mifepristone (gynecologic)) + Necon 1/35 (norethindrone/ ethinyl estradiol)
Avoid/Use Alternative mifepristone + ethinyl estradiol (contraceptive) use alternative non-hormonal contraception during and x1mo after daily mifepristone use: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (hepatic metabolism inhibited) mifepristone + norethindrone (contraceptive) use alternative non-hormonal contraception during and x1mo after daily mifepristone use: combo may decr. hormonal contraceptive efficacy (antagonistic effects)
Monitor/Modify Tx
Loreev XR (lorazepam) + Necon 1/35 (norethindrone/ ethinyl estradiol)
Monitor/Modify Tx lorazepam + ethinyl estradiol (contraceptive) consider lorazepam dose adjustment: combo may decr. lorazepam levels, efficacy (mechanism unknown)
Necon 1/35 (norethindrone/ ethinyl estradiol) + Primatene Tablets (ephedrine)
Monitor/Modify Tx ethinyl estradiol (contraceptive) + ephedrine oral monitor BP: combo may incr. risk of HTN (additive effects)
Additional Considerations
ephedrine oral in Primatene Tablets
add MAO inhibitor to Interaction Check if recent (14 days) use