palonosetron + solifenacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

palonosetron + metoclopramide

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

vinpocetine + fluoxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

carvedilol + metoclopramide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

carvedilol + licorice

monitor BP w/ large amounts of licorice: combo may decr. antihypertensive agent efficacy (antagonistic effects)

carvedilol + propofol

monitor BP, HR: combo may incr. risk of severe hypotension, bradycardia (additive effects)

carvedilol + fluoxetine

monitor BP, HR: combo may incr. carvedilol levels, risk of hypotension, bradycardia, AV block, other adverse effects (hepatic metab. inhibited)

carvedilol + oxcarbazepine

monitor BP, HR: combo may decr. carvedilol levels, efficacy (P-gp-mediated transport possibly induced)

metoclopramide + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

propofol + oxcarbazepine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, propofol may decr. seizure threshold)

fluoxetine + oxcarbazepine

monitor sodium: combo may incr. risk of hyponatremia, seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)

amoxicillin + oxcarbazepine

caution advised if seizure disorder use, especially w/ high amoxicillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, amoxicillin may decr. seizure threshold)

fluoxetine + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

fluoxetine + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dantrolene + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dantrolene + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

solifenacin + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)