Interaction Check

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Selected Drugs Clear All

MultiCheck Results - 5 Interactions

Avoid/Use Alternative
Besremi (ropeginterferon alfa-2b-njft) (ropeginterferon alfa-2b) + Septra (sulfamethoxazole/ trimethoprim)
Avoid/Use Alternative ropeginterferon alfa-2b + trimethoprim use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)
Besremi (ropeginterferon alfa-2b-njft) (ropeginterferon alfa-2b) + Zyrtec-D Allergy & Congestion (cetirizine/ pseudoephedrine)
Avoid/Use Alternative ropeginterferon alfa-2b + cetirizine use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
Mounjaro (tirzepatide) + Zyrtec-D Allergy & Congestion (cetirizine/ pseudoephedrine)
Monitor/Modify Tx tirzepatide + pseudoephedrine monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)
Caution Advised
Mounjaro (tirzepatide) + Septra (sulfamethoxazole/ trimethoprim)
Caution Advised tirzepatide + sulfamethoxazole caution advised w/ oral sulfamethoxazole: combo may decr. sulfamethoxazole levels, efficacy (absorption delayed, possibly decreased) tirzepatide + trimethoprim caution advised w/ oral trimethoprim: combo may decr. trimethoprim levels, efficacy (absorption delayed, possibly decreased)
Additional Considerations
ropeginterferon alfa-2b in Besremi (ropeginterferon alfa-2b-njft)
caution advised with narrow therapeutic index drugs; interferons may suppress CYP450 enzyme activity, resulting in incr. exposure of CYP substrates
tirzepatide in Mounjaro
caution advised with oral drugs, especially narrow therapeutic index; tirzepatide delays gastric emptying, may alter absorption of concomitant oral drugs
pseudoephedrine in Zyrtec-D Allergy & Congestion
add MAO inhibitor to Interaction Check if recent (14 days) use