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Interaction Check

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Selected Drugs Clear All

  • remove Adderall XR
    dextroamphetamine/ amphetamine
  • remove Lokelma
    sodium zirconium cyclosilicate
  • remove RectiCare Advanced Cream
    lidocaine/ phenylephrine/ mineral oil/ petrolatum topical

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Adderall XR (dextroamphetamine/ amphetamine) + Lokelma (sodium zirconium cyclosilicate)

Avoid/Use Alternative


amphetamine + sodium zirconium cyclosilicate

use alternative or monitor BP, HR: combo may incr. amphetamine levels, risk of adverse effects (absorption increased at higher gastric pH)

dextroamphetamine + sodium zirconium cyclosilicate

use alternative or monitor BP, HR w/ oral dextroamphetamine: combo may incr. dextroamphetamine levels, risk of adverse effects (absorption increased at higher gastric pH)

Additional Considerations

Smiley face Smiley face amphetamine in Adderall XR

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and Adzenys XR-ODT, Dyanavel XR, Mydayis, generic extended-release orally disintegrating tablet (ER ODT) formulations; combo may incr. amphetamine release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face dextroamphetamine in Adderall XR

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and Mydayis; combo may incr. dextroamphetamine release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face sodium zirconium cyclosilicate in Lokelma

separate administration from other oral drugs by at least 2h; sodium zirconium cyclosilicate may decr. absorption of concomitant oral drugs

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