Selected Drugs Clear All
MultiCheck Results
- 15
Interactions
Avoid/Use Alternative |
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Depacon
(valproate sodium) + valproate sodium
(generic) |
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Avoid/Use Alternativevalproic acid + valproic acid avoid combo: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy) |
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diazepam rectal
(generic) + Libervant
(diazepam transmucosal) |
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Avoid/Use Alternativediazepam + diazepam use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy) |
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Monitor/Modify Tx |
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Depacon
(valproate sodium) + diazepam rectal
(generic) |
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Monitor/Modify Txvalproic acid + diazepam monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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Depacon
(valproate sodium) + Equetro
(carbamazepine) |
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Monitor/Modify Txvalproic acid + carbamazepine monitor levels of both drugs: combo may decr. valproic acid levels, efficacy; may incr. carbamazepine active metabolite levels, risk of CNS depression, psychomotor impairment, other adverse effects (UGT induced; epoxide hydrolase inhibited, additive effects) |
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Depacon
(valproate sodium) + Libervant
(diazepam transmucosal) |
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Monitor/Modify Txvalproic acid + diazepam monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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diazepam rectal
(generic) + Equetro
(carbamazepine) |
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Monitor/Modify Txdiazepam + carbamazepine monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects) |
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diazepam rectal
(generic) + Motpoly XR
(lacosamide) |
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Monitor/Modify Txdiazepam + lacosamide monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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diazepam rectal
(generic) + valproate sodium
(generic) |
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Monitor/Modify Txdiazepam + valproic acid monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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Equetro
(carbamazepine) + Libervant
(diazepam transmucosal) |
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Monitor/Modify Txcarbamazepine + diazepam monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects) |
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Equetro
(carbamazepine) + Motpoly XR
(lacosamide) |
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Monitor/Modify Txcarbamazepine + lacosamide monitor HR, ECG, especially during lacosamide initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, PR interval prolongation, AV block, bradycardia (additive effects) |
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Equetro
(carbamazepine) + valproate sodium
(generic) |
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Monitor/Modify Txcarbamazepine + valproic acid monitor levels of both drugs: combo may decr. valproic acid levels, efficacy; may incr. carbamazepine active metabolite levels, risk of CNS depression, psychomotor impairment, other adverse effects (UGT induced; epoxide hydrolase inhibited, additive effects) |
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Libervant
(diazepam transmucosal) + Motpoly XR
(lacosamide) |
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Monitor/Modify Txdiazepam + lacosamide monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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Libervant
(diazepam transmucosal) + valproate sodium
(generic) |
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Monitor/Modify Txdiazepam + valproic acid monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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Caution Advised |
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Depacon
(valproate sodium) + Motpoly XR
(lacosamide) |
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Caution Advisedvalproic acid + lacosamide caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects) |
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Motpoly XR
(lacosamide) + valproate sodium
(generic) |
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Caution Advisedlacosamide + valproic acid caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects) |
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Additional Considerations |
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carbamazepine
in Equetro
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add MAO inhibitor to Interaction Check if recent (14 days) use some formulations of carbamazepine contain sorbitol |
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