Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Avoid/Use Alternative |
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amoxapine
(generic) + hydromorphone
(generic) |
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Avoid/Use Alternativeamoxapine + hydromorphone use alternative or monitor respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects) |
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Monitor/Modify Tx |
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amoxapine
(generic) + thiothixene
(generic) |
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Monitor/Modify Txamoxapine + thiothixene monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects) |
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hydromorphone
(generic) + thiothixene
(generic) |
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Monitor/Modify Txhydromorphone + thiothixene monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects) |
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Additional Considerations |
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hydromorphone
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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amoxapine
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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