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Interaction Check

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Selected Drugs Clear All

  • remove imipramine
    generic
  • remove Ongentys
    opicapone
  • remove Sandostatin LAR Depot
    octreotide

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face imipramine (generic) + Ongentys (opicapone)

Monitor/Modify Tx


imipramine + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

Additional Considerations

Smiley face Smiley face octreotide in Sandostatin LAR Depot

caution advised with narrow therapeutic index drugs extensively metabolized by CYP450 liver enzymes; octreotide inhibition of growth hormone production may decr. CYP450 metabolic function, incr. levels of concomitant drugs, risk of adverse effects

caution advised with oral drugs; octreotide alters nutrient absorption, may alter absorption of concomitant drugs, incr. risk of adverse effects or decr. efficacy

Smiley face Smiley face imipramine

add MAO inhibitor to Interaction Check if recent (14 days) use

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