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Interaction Check

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Selected Drugs Clear All

  • remove Cresemba
    isavuconazonium sulfate
  • remove Daytrana
    methylphenidate transdermal
  • remove griseofulvin microsize
    generic
  • remove ketoconazole
    generic
  • remove Mephyton
    phytonadione (vitamin K1)
  • remove Phillips' Milk of Magnesia
    magnesium hydroxide
  • remove Sandostatin
    octreotide
  • remove Tindamax
    tinidazole

multicheck MultiCheck Results - 8 Interactions

Smiley face Smiley face

Contraindicated

Smiley face Smiley face Cresemba (isavuconazonium sulfate) + ketoconazole (generic)

Contraindicated


isavuconazonium + ketoconazole

contraindicated during and up to 1wk after ketoconazole tx: combo may incr. isavuconazole levels, risk of adverse effects (hepatic metabolism inhibited)

Avoid/Use Alternative

Smiley face Smiley face Daytrana (methylphenidate transdermal) + Phillips' Milk of Magnesia (magnesium hydroxide)

Avoid/Use Alternative


methylphenidate + magnesium hydroxide

consider alternative w/ some oral methylphenidate ER formulations: combo may alter methylphenidate release, incr. risk of adverse effects or decr. efficacy (altered dissolution of ER methylphenidate at higher gastric pH)

Monitor/Modify Tx

Smiley face Smiley face griseofulvin microsize (generic) + ketoconazole (generic)

Monitor/Modify Tx


griseofulvin + ketoconazole

monitor for breakthrough fungal infection: combo may decr. ketoconazole levels, efficacy (hepatic metabolism induced)

Smiley face Smiley face ketoconazole (generic) + Phillips' Milk of Magnesia (magnesium hydroxide)

Monitor/Modify Tx


ketoconazole + magnesium hydroxide

give ketoconazole 2h before or 1h after magnesium hydroxide; admin. w/ acidic beverage; monitor for breakthrough fungal infection: combo may decr. ketoconazole levels, efficacy (absorption decreased at higher gastric pH)

Smiley face Smiley face Phillips' Milk of Magnesia (magnesium hydroxide) + Sandostatin (octreotide)

Monitor/Modify Tx


magnesium hydroxide + octreotide

consider giving oral octreotide 2h before or after magnesium hydroxide: combo may decr. octreotide levels, efficacy (absorption decreased at higher gastric pH)

Caution Advised

Smiley face Smiley face Cresemba (isavuconazonium sulfate) + griseofulvin microsize (generic)

Caution Advised


isavuconazonium + griseofulvin

caution advised: combo may decr. isavuconazole levels, efficacy (hepatic metabolism induced)

Smiley face Smiley face ketoconazole (generic) + Mephyton (phytonadione (vitamin K1))

Caution Advised


ketoconazole + vitamin K

caution advised: combo may incr. vitamin K levels, risk of adverse effects (hepatic metabolism inhibited)

Smiley face Smiley face ketoconazole (generic) + Tindamax (tinidazole)

Caution Advised


ketoconazole + tinidazole

caution advised: combo may incr. tinidazole levels, risk of adverse effects (hepatic metabolism inhibited)

Additional Considerations

Smiley face Smiley face methylphenidate in Daytrana

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face isavuconazonium in Cresemba

isavuconazonium (prodrug) converted to isavuconazole

Smiley face Smiley face ketoconazole

avoid combo with alcoholic beverages or products containing ethanol; combo may incr. risk of disulfiram-like reaction

Smiley face Smiley face tinidazole in Tindamax

avoid combo with alcoholic beverages or products containing ethanol or propylene glycol during and x3 days after tinidazole tx; combo may incr. risk of disulfiram-like reaction

Smiley face Smiley face octreotide in Sandostatin

caution advised with narrow therapeutic index drugs extensively metabolized by CYP450 liver enzymes; octreotide inhibition of growth hormone production may decr. CYP450 metabolic function, incr. levels of concomitant drugs, risk of adverse effects

caution advised with oral drugs; octreotide alters nutrient absorption, may alter absorption of concomitant drugs, incr. risk of adverse effects or decr. efficacy

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