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Interaction Check

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Selected Drugs Clear All

  • remove Pirmella 1/ 35
    norethindrone/ ethinyl estradiol
  • remove REGEN-COV
    casirivimab and imdevimab
  • remove Reglan
    metoclopramide
  • remove Reyataz
    atazanavir

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Pirmella 1/35 (norethindrone/ ethinyl estradiol) + Reyataz (atazanavir)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + atazanavir

monitor thrombosis s/sx, especially if oral ethinyl estradiol dose at least 35 mcg/day; ATAZANAVIR W/ RITONAVIR: use additional non-hormonal or alternative contraception if ethinyl estradiol dose <35 mcg/day (induction predominates); ATAZANAVIR W/O RITONAVIR: avoid combo if ethinyl estradiol dose at least 30 mcg/day (inhibition predominates); ATAZANAVIR W/ COBICISTAT: consider additional non-hormonal or alternative contraception (effects unknown): combo may incr. or decr. ethinyl estradiol levels, incr. risk of thromboembolism, other adverse effects or decr. hormonal contraceptive efficacy (hepatic metabolism altered, UGT inhibited)

Monitor/Modify Tx


norethindrone (contraceptive) + atazanavir

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. norethindrone levels, risk of thromboembolism, other adverse effects (hepatic metabolism possibly inhibited)

Monitor/Modify Tx

Smiley face Smiley face Pirmella 1/35 (norethindrone/ ethinyl estradiol) + Reglan (metoclopramide)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + metoclopramide

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face casirivimab (REGN10933) in REGEN-COV

FDA emergency use authorization revoked

Smiley face Smiley face imdevimab (REGN10987) in REGEN-COV

FDA emergency use authorization revoked

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