Selected Drugs Clear All
MultiCheck Results
- 4
Interactions
Avoid/Use Alternative |
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Mavyret
(glecaprevir/ pibrentasvir) + OxyFast
(oxycodone) |
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Avoid/Use Alternativeglecaprevir + oxycodone use alternative or monitor respiratory rate; consider decr. oxycodone dose: combo may incr. oxycodone levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited) pibrentasvir + oxycodone use alternative or monitor respiratory rate; consider decr. oxycodone dose: combo may incr. oxycodone levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited) |
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Monitor/Modify Tx |
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cetirizine
(generic) + OxyFast
(oxycodone) |
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Monitor/Modify Txcetirizine + oxycodone monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. cetirizine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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OxyFast
(oxycodone) + Prinivil
(lisinopril) |
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Monitor/Modify Txoxycodone + lisinopril monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects) |
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Additional Considerations |
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oxycodone
in OxyFast
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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pibrentasvir
in Mavyret
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caution advised with narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose with drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia |
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glecaprevir
in Mavyret
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caution advised w/ narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose w/ drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia |
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