Interaction Check

This page cannot be displayed because your browser has been configured to disable JavaScript, also known as "Active Scripting".Please change your settings and refresh the page.

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

MultiCheck Results - 3 Interactions

Avoid/Use Alternative
grape seed extract (grape (Vitis spp.)) + Junel 1.5/30 (norethindrone/ ethinyl estradiol)
Avoid/Use Alternative grape + ethinyl estradiol (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after grape tx: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metabolism induced)
Monitor/Modify Tx
Junel 1.5/30 (norethindrone/ ethinyl estradiol) + Ofev (nintedanib)
Monitor/Modify Tx ethinyl estradiol (contraceptive) + nintedanib monitor thrombosis s/sx: combo may incr. risk of thromboembolism (additive effects) norethindrone (contraceptive) + nintedanib monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)
Additional Considerations
ledipasvir in Harvoni
caution advised with narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose with drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia
sofosbuvir in Harvoni
caution advised w/ narrow therapeutic index drugs extensively metabolized in the liver; viral eradication may improve hepatic metabolic function, decr. levels, efficacy of concomitant drugs monitor glucose w/ drugs used for diabetes tx; viral eradication may change hepatic function, alter blood glucose control resulting in serious symptomatic hypoglycemia