epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Mucinex 12 Hour Cold & Fever Multi-Symptom
    naproxen/ dextromethorphan/ guaifenesin
  • remove Zomig Nasal
    zolmitriptan nasal

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Mucinex 12 Hour Cold & Fever Multi-Symptom (naproxen/ dextromethorphan/ guaifenesin) + Zomig Nasal (zolmitriptan nasal)

Monitor/Modify Tx


dextromethorphan + zolmitriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

naproxen + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face zolmitriptan in Zomig Nasal

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Mucinex 12 Hour Cold & Fever Multi-Symptom

add MAO inhibitor to Interaction Check if recent (14 days) use

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information