Selected Drugs Clear All
MultiCheck Results
- 4
Interactions
Avoid/Use Alternative |
||
|
Brixadi
(buprenorphine) + promethazine/dextromethorphan
(generic) |
||
Avoid/Use Alternativebuprenorphine + dextromethorphan use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects) buprenorphine + promethazine use alternative or monitor respiratory rate, BP; decr. buprenorphine by at least 25-50%, consider decr. promethazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, seizures, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects) |
||
Monitor/Modify Tx |
||
|
Brixadi
(buprenorphine) + Venofer
(iron sucrose) |
||
|
promethazine/dextromethorphan
(generic) + Venofer
(iron sucrose) |
||
Additional Considerations |
||
|
buprenorphine
in Brixadi
|
||
|
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use |
||
|
dextromethorphan
in promethazine/dextromethorphan
|
||
|
add MAO inhibitor to Interaction Check if recent (14 days) use |
||