clozapine + ethinyl estradiol (contraceptive)

monitor ECG, BP, HR, thrombosis s/sx; consider decr. clozapine dose: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, thromboembolism, other adverse effects (hepatic metabolism inhibited, additive effects)

clozapine + levonorgestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)