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Interaction Check

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Selected Drugs Clear All

  • remove Advil PM
    ibuprofen/ diphenhydramine
  • remove Cleviprex
    clevidipine
  • remove EC-Naprosyn
    naproxen
  • remove Gleevec
    imatinib
  • remove Vandazole
    metronidazole vaginal
  • remove Zylet
    loteprednol/ tobramycin ophthalmic

multicheck MultiCheck Results - 5 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Advil PM (ibuprofen/ diphenhydramine) + EC-Naprosyn (naproxen)

Avoid/Use Alternative


ibuprofen + naproxen

avoid combo: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), thromboembolism, HTN, hyperkalemia, renal impairment, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Advil PM (ibuprofen/ diphenhydramine) + Cleviprex (clevidipine)

Monitor/Modify Tx


ibuprofen + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face Advil PM (ibuprofen/ diphenhydramine) + Gleevec (imatinib)

Monitor/Modify Tx


ibuprofen + imatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Smiley face Smiley face Cleviprex (clevidipine) + EC-Naprosyn (naproxen)

Monitor/Modify Tx


clevidipine + naproxen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face EC-Naprosyn (naproxen) + Gleevec (imatinib)

Monitor/Modify Tx


naproxen + imatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Additional Considerations

Smiley face Smiley face metronidazole vaginal in Vandazole

contraindicated with alcoholic beverages or products containing ethanol or propylene glycol during and x3 days after metronidazole vaginal 5-day tx or x24h after metronidazole vaginal single dose tx; combo may incr. risk of disulfiram-like reaction

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