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Interaction Check

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Selected Drugs Clear All

  • remove Aurovela Fe 1/ 20
    norethindrone/ ethinyl estradiol
  • remove mexiletine
    generic
  • remove Probuphine
    buprenorphine subdermal
  • remove Xgeva
    denosumab (oncologic)
  • remove Xopenex HFA
    levalbuterol inhaled

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Aurovela Fe 1/20 (norethindrone/ ethinyl estradiol) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

Smiley face Smiley face mexiletine (generic) + Probuphine (buprenorphine subdermal)

Caution Advised


mexiletine + buprenorphine

caution advised: combo may decr. peak mexiletine levels, delay antiarrhythmic onset (absorption delayed)

Additional Considerations

Smiley face Smiley face buprenorphine in Probuphine

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

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