Interaction Check

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MultiCheck Results - 4 Interactions

Avoid/Use Alternative
Depakote (divalproex sodium) + hydrocodone/acetaminophen (generic)
Avoid/Use Alternative valproic acid + hydrocodone avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, hydrocodone may decr. seizure threshold) Monitor/Modify Tx valproic acid + acetaminophen consider acetaminophen dose adjustment: combo may incr. acetaminophen levels, risk of adverse effects (UGT inhibited)
Caution Advised
amoxicillin/clavulanate (generic) + Depakote (divalproex sodium)
Caution Advised amoxicillin + valproic acid caution advised if seizure disorder use, especially w/ high amoxicillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, amoxicillin may decr. seizure threshold)
Depakote (divalproex sodium) + Lexiscan (regadenoson)
Caution Advised valproic acid + regadenoson caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, regadenoson may decr. seizure threshold)
Additional Considerations
hydrocodone in hydrocodone/acetaminophen
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy