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Interaction Check

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Selected Drugs Clear All

  • remove CagriSema
    cagrilintide/ semaglutide
  • remove Children's Mucinex Mighty Chews Cold & Flu
    acetaminophen/ dextromethorphan
  • remove darunavir
    generic
  • remove L-5 HTP
    5-HTP
  • remove R-alpha-lipoic acid
    alpha-lipoic acid

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face CagriSema (cagrilintide/ semaglutide) + darunavir (generic)

Monitor/Modify Tx


semaglutide + darunavir

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Children's Mucinex Mighty Chews Cold & Flu (acetaminophen/ dextromethorphan) + L-5 HTP (5-HTP)

Monitor/Modify Tx


dextromethorphan + 5-HTP

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Additional Considerations

Smiley face Smiley face dextromethorphan in Children's Mucinex Mighty Chews Cold & Flu

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face cagrilintide in CagriSema

pending FDA approval

Smiley face Smiley face semaglutide in CagriSema

caution advised with oral drugs, especially narrow therapeutic index; oral/SC semaglutide delays gastric emptying, may alter absorption of concomitant oral drugs

administer oral semaglutide at least 30 min before other oral drugs; combo may decr. oral semaglutide absorption, efficacy

Smiley face Smiley face 5-HTP in L-5 HTP

add MAO inhibitor to Interaction Check if recent (14 days) use

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