aliskiren + valsartan

contraindicated in diabetic patients; avoid combo in pts w/ CrCl <60; for all other pts, use alternative or monitor BP, potassium, renal fxn: combo may incr. risk of hypotension, hyperkalemia, renal impairment without additional benefit (additive effects, dual blockade of renin-angiotensin-aldosterone system)

aliskiren + sacubitril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)