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Interaction Check

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Selected Drugs Clear All

  • remove Ritalin SR
    methylphenidate
  • remove Vyvanse
    lisdexamfetamine

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Ritalin SR (methylphenidate) + Vyvanse (lisdexamfetamine)

Avoid/Use Alternative


methylphenidate + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor BP, HR, serotonin syndrome symptoms, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN, tachycardia, other adverse effects (additive effects, duplicate therapy)

Additional Considerations

Smiley face Smiley face methylphenidate in Ritalin SR

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face lisdexamfetamine in Vyvanse

lisdexamfetamine (prodrug) converted to dextroamphetamine

add MAO inhibitor to Interaction Check if recent (14 days) use

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