Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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hydrocodone/acetaminophen
(generic) + Seroquel XR
(quetiapine) |
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Avoid/Use Alternativehydrocodone + quetiapine avoid combo if antitussive use; otherwise monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects) |
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Monitor/Modify Tx |
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Seroquel XR
(quetiapine) + Strattera
(atomoxetine) |
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Monitor/Modify Txquetiapine + atomoxetine monitor BP, especially in pts <18 yo: combo may incr. risk of HTN (additive effects) |
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Additional Considerations |
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atomoxetine
in Strattera
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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hydrocodone
in hydrocodone/acetaminophen
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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