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Interaction Check

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Selected Drugs Clear All

  • remove acetaminophen/ codeine
    generic
  • remove bicalutamide
    generic

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face acetaminophen/codeine (generic) + bicalutamide (generic)

Avoid/Use Alternative


codeine + bicalutamide

use alternative or monitor respiratory rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine)

Additional Considerations

Smiley face Smiley face codeine in acetaminophen/codeine

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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