Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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Zamicet
(hydrocodone/ acetaminophen) + Zenchent
(norethindrone/ ethinyl estradiol) |
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Avoid/Use Alternativehydrocodone + ethinyl estradiol (contraceptive) use alternative or monitor respiratory rate, ECG, consider decr. (benz)hydrocodone dose: combo may incr. hydrocodone levels, risk of CNS and respiratory depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited) Monitor/Modify Txacetaminophen + ethinyl estradiol (contraceptive) monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown) |
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Additional Considerations |
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hydrocodone
in Zamicet
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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