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Interaction Check

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Selected Drugs Clear All

  • remove doxylamine
    generic
  • remove nabumetone
    generic
  • remove Pulmicort Respules
    budesonide inhaled
  • remove Zepbound
    tirzepatide
  • remove Zyprexa
    olanzapine

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face doxylamine (generic) + Zyprexa (olanzapine)

Avoid/Use Alternative


doxylamine + olanzapine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Zepbound (tirzepatide) + Zyprexa (olanzapine)

Monitor/Modify Tx


tirzepatide + olanzapine

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Additional Considerations

Smiley face Smiley face tirzepatide in Zepbound

caution advised with oral drugs, especially narrow therapeutic index; tirzepatide delays gastric emptying, may alter absorption of concomitant oral drugs

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