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Interaction Check

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Selected Drugs Clear All

  • remove Acuvail
    ketorolac ophthalmic
  • remove Apidra
    insulin glulisine
  • remove Cipro
    ciprofloxacin
  • remove Junel 1.5/ 30
    norethindrone/ ethinyl estradiol
  • remove ketoprofen
    generic
  • remove Morphabond ER
    morphine sulfate
  • remove RectiCare Advanced Cream
    lidocaine/ phenylephrine/ mineral oil/ petrolatum topical
  • remove Xopenex HFA
    levalbuterol inhaled
  • remove Zostavax
    zoster vaccine, live (ZVL)

multicheck MultiCheck Results - 11 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Acuvail (ketorolac ophthalmic) + ketoprofen (generic)

Monitor/Modify Tx


ketorolac ophthalmic + ketoprofen

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

Smiley face Smiley face Apidra (insulin glulisine) + Cipro (ciprofloxacin)

Monitor/Modify Tx


insulin + ciprofloxacin

monitor glucose: combo may alter glycemic control, incr. risk of hyperglycemia or severe hypoglycemia, including life-threatening (additive effects, antagonistic effects, fluoroquinolones may alter blood glucose)

Smiley face Smiley face Apidra (insulin glulisine) + Junel 1.5/30 (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


insulin + ethinyl estradiol (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

insulin + norethindrone (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Apidra (insulin glulisine) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


insulin + levalbuterol inhaled

monitor potassium: combo may incr. risk of hypokalemia (additive effects)

Smiley face Smiley face Cipro (ciprofloxacin) + Junel 1.5/30 (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


ciprofloxacin + ethinyl estradiol (contraceptive)

monitor thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (hepatic metabolism inhibited)

Smiley face Smiley face Junel 1.5/30 (norethindrone/ ethinyl estradiol) + ketoprofen (generic)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + ketoprofen

monitor BP, thrombosis s/sx; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

norethindrone (contraceptive) + ketoprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face Junel 1.5/30 (norethindrone/ ethinyl estradiol) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face ketoprofen (generic) + Xopenex HFA (levalbuterol inhaled)

Monitor/Modify Tx


ketoprofen + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

Smiley face Smiley face Cipro (ciprofloxacin) + ketoprofen (generic)

Caution Advised


ciprofloxacin + ketoprofen

caution advised: combo may incr. risk of CNS stimulation, seizures (mechanism unknown)

Additional Considerations

Smiley face Smiley face morphine in Morphabond ER

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy

Smiley face Smiley face zoster vaccine, live in Zostavax

Discontinued in US

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