garlic + ethinyl estradiol (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after supplemental garlic tx; dietary intake OK: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metab. induced)

garlic + norethindrone (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after supplemental garlic tx; dietary intake OK: combo may decr. norethindrone levels, contraceptive efficacy (hepatic metab. induced)

garlic + clozapine

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

garlic + cariprazine

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

clozapine + ethinyl estradiol (contraceptive)

monitor ECG, BP, HR, thrombosis s/sx; consider decr. clozapine dose: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, thromboembolism, other adverse effects (hepatic metab. inhibited, additive effects)

clozapine + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)

clozapine + cariprazine

monitor BP, HR: combo may incr. risk of CNS depression, psychomotor impairment, seizures, extrapyramidal symptoms, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects, duplicate tx)

garlic + tasimelteon

caution advised w/ supplemental garlic; dietary intake OK: combo may decr. tasimelteon levels, efficacy (hepatic metab. induced)

clozapine + cefiderocol

caution advised, especially w/ high cefiderocol doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

clozapine + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

tasimelteon + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

ethinyl estradiol (contraceptive) + cariprazine

caution advised: combo may incr. cariprazine and active metabolite levels, risk of adverse effects (hepatic metab. inhibited)