Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Contraindicated |
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methadone
(generic) + posaconazole
(generic) |
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Contraindicatedmethadone + posaconazole contraindicated: combo may incr. methadone levels, risk of CNS and respiratory depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited; additive effects) |
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Monitor/Modify Tx |
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amphotericin B deoxycholate
(generic) + posaconazole
(generic) |
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Monitor/Modify Txamphotericin + posaconazole monitor potassium, ECG: combo may incr. risk of hypokalemia, cardiac arrhythmias (additive effects) |
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Caution Advised |
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Grifulvin V
(griseofulvin microsize) + methadone
(generic) |
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Caution Advisedgriseofulvin + methadone caution advised: combo may decr. methadone levels, efficacy (hepatic metabolism induced) |
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Additional Considerations |
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posaconazole
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some formulations of posaconazole contain sorbitol avoid combo with beverages or products containing ethanol and posaconazole delayed-release (DR) oral suspension; combo may incr. posaconazole release rate, levels, risk of adverse effects |
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methadone
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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