cabozantinib + valbenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

cabozantinib + paroxetine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

cabozantinib + tenofovir alafenamide

monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

cabozantinib + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

valbenazine + paroxetine

monitor ECG; decr. valbenazine dose to 40 mg qd: combo may incr. valbenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

valbenazine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

valbenazine + tenofovir alafenamide

if tenofovir alafenamide not admin. w/ cobicistat, monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (gut P-gp-mediated transport inhibited)

paroxetine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. fluphenazine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

paroxetine + tenofovir alafenamide

if tenofovir alafenamide not admin. w/ cobicistat, monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (gut P-gp-mediated transport inhibited)

paroxetine + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)