epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove liothyronine
    generic
  • remove norgestimate/ ethinyl estradiol
    generic
  • remove Topamax
    topiramate

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face norgestimate/ethinyl estradiol (generic) + Topamax (topiramate)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + topiramate

use additional non-hormonal or alternative contraception during and x28 days after topiramate tx, especially w/ topiramate doses >200 mg/day: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metabolism induced)

norgestimate (contraceptive) + topiramate

use additional non-hormonal or alternative contraception during and x28 days after topiramate tx, especially w/ topiramate doses >200 mg/day: combo may decr. norgestimate and active metabolites levels, contraceptive efficacy (hepatic metabolism induced)

Monitor/Modify Tx

Smiley face Smiley face liothyronine (generic) + norgestimate/ethinyl estradiol (generic)

Monitor/Modify Tx


liothyronine + ethinyl estradiol (contraceptive)

monitor thyroid fxn: combo may decr. thyroid hormone efficacy (thyroid hormone uptake altered)

Additional Considerations

Smiley face Smiley face topiramate in Topamax

beverages or products containing ethanol are contraindicated within 6h of topiramate extended-release (ER) capsules administration; combo may incr. topiramate release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face liothyronine

monitor thyroid function more frequently when starting, adjusting, or stopping other drugs, including short-term therapies, OTC drugs, herbal supplements

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information