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Interaction Check

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Selected Drugs Clear All

  • remove Cheratussin AC
    codeine/ guaifenesin
  • remove Fabhalta
    iptacopan
  • remove Flovent HFA
    fluticasone propionate inhaled
  • remove minoxidil
    generic
  • remove olanzapine
    generic
  • remove Tribenzor
    olmesartan medoxomil/ amlodipine/ hydrochlorothiazide

multicheck MultiCheck Results - 10 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Cheratussin AC (codeine/ guaifenesin) + olanzapine (generic)

Avoid/Use Alternative


codeine + olanzapine

avoid combo if antitussive use; otherwise, consider alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus (including life-threatening), urinary retention (additive effects)

Smiley face Smiley face Cheratussin AC (codeine/ guaifenesin) + Tribenzor (olmesartan medoxomil/ amlodipine/ hydrochlorothiazide)

Avoid/Use Alternative


codeine + amlodipine

use alternative or monitor respiratory rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine; additive effects)

Monitor/Modify Tx


codeine + hydrochlorothiazide

monitor BP: combo may decr. hydrochlorothiazide efficacy; may incr. risk of severe hypotension, including orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

codeine + olmesartan medoxomil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Cheratussin AC (codeine/ guaifenesin) + minoxidil (generic)

Monitor/Modify Tx


codeine + minoxidil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

Smiley face Smiley face minoxidil (generic) + olanzapine (generic)

Monitor/Modify Tx


minoxidil + olanzapine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

Smiley face Smiley face olanzapine (generic) + Tribenzor (olmesartan medoxomil/ amlodipine/ hydrochlorothiazide)

Monitor/Modify Tx


olanzapine + amlodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

olanzapine + hydrochlorothiazide

monitor BP: combo may incr. hydrochlorothiazide levels, risk of hypotension (including orthostasis, syncope), other adverse effects (absorption increased, additive effects)

olanzapine + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

Caution Advised

Smiley face Smiley face Fabhalta (iptacopan) + Flovent HFA (fluticasone propionate inhaled)

Caution Advised


iptacopan + fluticasone propionate

caution advised: combo may incr. risk of serious infection (additive effects)

Additional Considerations

Smiley face Smiley face codeine in Cheratussin AC

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face amlodipine in Tribenzor

levamlodipine is the active isomer of racemic amlodipine; similar interactions anticipated

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