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Interaction Check

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Selected Drugs Clear All

  • remove Depo-Estradiol
    estradiol cypionate
  • remove Sronyx
    levonorgestrel/ ethinyl estradiol
  • remove Zubsolv
    buprenorphine/ naloxone

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Depo-Estradiol (estradiol cypionate) + Sronyx (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


estradiol (hormone replacement) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx


estradiol (hormone replacement) + levonorgestrel (contraceptive)

monitor thrombosis s/sx: combo may incr. risk of thromboembolism (additive effects)

Additional Considerations

Smiley face Smiley face buprenorphine in Zubsolv

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

Smiley face Smiley face naloxone (abuse deterrent) in Zubsolv

no pharmacologic activity when administered as directed

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