Selected Drugs Clear All
MultiCheck Results
- 4
Interactions
Avoid/Use Alternative |
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Augtyro
(repotrectinib) + Idhifa
(enasidenib) |
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Avoid/Use Alternativerepotrectinib + enasidenib avoid combo: combo may incr. or decr. repotrectinib levels, incr. risk of adverse effects or decr. efficacy (P-gp-mediated transport inhibited, hepatic metabolism induced) |
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Monitor/Modify Tx |
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Augtyro
(repotrectinib) + Onfi
(clobazam) |
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Monitor/Modify Txrepotrectinib + clobazam monitor respiratory rate: combo may decr. repotrectinib levels, efficacy; may incr. risk of CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects) |
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Idhifa
(enasidenib) + Onfi
(clobazam) |
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Monitor/Modify Txenasidenib + clobazam monitor respiratory rate: combo may incr. clobazam and active metabolite levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited) |
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Caution Advised |
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Onfi
(clobazam) + Suprep
(sodium sulfate/ potassium sulfate/ magnesium sulfate) |
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Caution Advisedclobazam + sulfate bowel prep caution advised: combo may alter seizure control (antagonistic effects, sulfate bowel prep may decr. seizure threshold) |
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Additional Considerations |
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sulfate bowel prep
in Suprep
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separate administration from other oral drugs by at least 1h; sulfate bowel prep may decr. absorption of concomitant oral drugs |
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