Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Avoid/Use Alternative |
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Lo Loestrin Fe
(norethindrone/ ethinyl estradiol) + Paxlovid
(nirmatrelvir and ritonavir) |
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Avoid/Use Alternativeethinyl estradiol (contraceptive) + ritonavir FOR ALL INDICATIONS: monitor thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day; FIXED-DOSE COMBO FOR COVID-19 INFECTION: use additional non-hormonal or alternative contraception during nirmatrelvir/ritonavir tx and through one complete menstrual cycle after nirmatrelvir/ritonavir D/C; HIV INFECTION: use additional non-hormonal or alternative contraception during and x28 days after ritonavir tx: combo may decr. ethinyl estradiol levels, contraceptive efficacy; may initially incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (hepatic metabolism induced, UGT induced; hepatic metabolism inhibited) norethindrone (contraceptive) + ritonavir FOR ALL INDICATIONS: monitor thrombosis s/sx; FIXED-DOSE COMBO FOR COVID-19 INFECTION: use additional non-hormonal or alternative contraception during nirmatrelvir/ritonavir tx and through one complete menstrual cycle after nirmatrelvir/ritonavir D/C; HIV INFECTION: use additional non-hormonal or alternative contraception during and x28 days after ritonavir tx: combo may incr. or decr. norethindrone levels, incr. risk of thromboembolism, other adverse effects or decr. contraceptive efficacy (hepatic metabolism altered) |
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Monitor/Modify Tx |
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Inzirqo
(hydrochlorothiazide) + Lo Loestrin Fe
(norethindrone/ ethinyl estradiol) |
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Monitor/Modify Txhydrochlorothiazide + ethinyl estradiol (contraceptive) monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects) |
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Additional Considerations |
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nirmatrelvir
in Paxlovid
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patients on ritonavir- or cobicistat-containing HIV or HCV regimens may continue their tx as indicated |
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